In the past, the war between humans and vampires has devastated the world. The Church created an elite spiritual warrior organization, dubbed "Priests", who were capable of slaying vampires. The majority of the vampires were killed while the remainder were placed in reservations. The Church created isolated, heavily guarded cities. No longer needing the Priests' services, and fearing their own weapon, the Church disbanded them. Outside the cities humans live outside the totalitarian control of the Church.
One day, a Priest is approached by Hicks, the sheriff of a nearby town. Hicks tells him that his brother Owen was mortally wounded and his sister-in-law and ex-girlfriend Shannon was killed by vampires and Priest's niece, Lucy, was kidnapped. Hicks asks for Priest's assistance in tracking down Lucy. Priest goes against the wishes of Monsignor Orelas, the Church's leader, to do so. Monsignor Orelas then sends a group of four Priests led by Priestess to capture him and bring him back, dead or alive.
